교수소개
교수소개
 학과소개 교수소개
이름
신인지
전공
유기화학/유기합성/의약화학
TEL
02-970-6690
E-mail
inji@seoultech.ac.kr
연구실
청운관 250호
교수소개 돌아가기
학력
2013 University of Pennsylvania (UPENN), Department of Chemistry, 이학박사 (PhD)
2007 한양대학교 화학과, 이학석사 (MS)
2005 한양대학교 화학과, 이학사 (BS)
주요 경력
2019-현재 서울과학기술대학교 정밀화학과 조교수
2016-2019 한국화학연구원 선임연구원
2013-2016 University of Texas at Austin, Postdoctoral Fellow
연구 분야
유기합성 - 유기반응 개발 및 천연물 합성
유기금속촉매 반응
의약화학
화장품화학
주요논문 및 저서
◾ Recent Advances in One-Pot Modular Synthesis of 2-Quinolones / Hong, W. P.; Shin, I*; Lim, H. N.* Molecules 2020, 25, 5450.
◾ Development and Structure-Activity Relationship Study of SHP2 Inhibitor containing 3,4,6-trihydroxy-5-oxo-5H-benzo[7]annulene / Kim, B.; Jo, S.; Park, S. B.; Chae, C. H.; Lee, K.; Koh, B.; Shin, I* Bioorg. Med. Chem. Lett. 2020, 30, 126756.
◾ Chan-Lam Coupling Reaction of Sulfamoyl Azides with Arylboronic Acids for Synthesis of Unsymmetrical N-Arylsulfamides / Won, S.-Y.; Kim, S.-E.; Kwon, Y.-J.; Shin, I.; Ham, J.; Kim, W.-S.* RSC Advances 2019, 9, 2493.
◾ Allosteric Inhibitor TREA-0236 Containing Non-hydrolysable Quinazoline-3-one for EGFR T790M/C797S Mutants Inhibition / Lee, S.; Kim, J.; Duggirala, K. B.; Go, A.; Shin, I.; Cho, B. C.; Choi, G.*; Chae, C. H.*; Lee, K.* Bull. Korean Chem. Soc. 2018, 39, 895.
◾ 3-Hydroxy-2-(Trialkylsilyl)phenyl Triflate: A Benzyne Precursor Triggered via 1,3-C-sp2-O Silyl Migration / Kwon, Y.-J.; Jeon Y.-K.; Sim, H.-B.; Oh, I.-Y.; Shin, I.; Kim, W.-S.* Org. Lett. 2017, 19, 6224.
◾ Structure-Activity Relationship Study of 2,4-Dianilinopyrimidine Containing Methanesulfonamide (TRE-069) as Potent and Selective Epidermal Growth Factor Receptor T790M/C797S Mutant Inhibitor for Anticancer Treatment / Choe, H.; Jeon, B. U.; Jung, M. E.; Jeon, M.-K.; Shin, I.; Cho, B. C.; Choi, G.*; Chae, C. H.*; Lee, K.* Bull. Korean Chem. Soc. 2017, 38, 1353.
◾ Total Synthesis of Swinholide A: An Exposition in Hydrogen-Mediated C–C Bond Formation / Shin, I.; Hong, S.; Krische, M. J.* J. Am. Chem. Soc. 2016, 138, 14246.
◾ Asymmetric Iridium-Catalyzed C–C Coupling of Chiral Diols via Site-Selective Redox-Triggered Carbonyl Addition / Shin, I.; Krische, M. J.* Top. Current Chem. 2016, 372, 85.
◾ Formal Synthesis of Premisakinolide A and C(19)–C(32) of Swinholide A via Site-Selective C–H Allylation and Crotylation of Unprotected Diols / Shin, I.; Krische, M. J.* Org. Lett. 2015, 17, 4686.
◾ Reductive Cyclization of Halo-Ketones to Form 3-Hydroxy-2-Oxindoles via Palladium Catalyzed Hydrogenation: A Hydrogen-Mediated Grignard Addition / Shin, I.; Ramgren, S. D.; Krische, M. J.* Tetrahedron, 2015, 71, 5776.
◾ Catalytic C–C Bond Formation and the Hendricksonian Ideal: Atom- and Redox-Economy, Stereo- and Site-Selectivity / Shin, I.; Montgomery, T. P.; Krische, M. J.* Aldrichimica Acta 2015, 48, 15.
◾ Catalyst-Directed Diastereo- and Site-Selectivity in Successive Nucleophilic and Electrophilic Allylations of Chiral 1,3-Diols: Protecting-Group-Free Synthesis of Substituted Pyrans / Shin, I.; Wang, G.; Krische, M. J.* Chem. Eur. J. 2014, 20, 13382.
◾ Catalytic Enantioselective C–H Functionalization of Alcohols by Redox-Triggered Carbonyl Addition: Borrowing Hydrogen, Returning Carbon / Ketcham, J. M.; Shin, I.; Montgomery, T. P.; Krische, M. J.* Angew. Chem. Int. Ed. 2014, 53, 9142.
◾ Pd-Catalyzed Suzuki–Miyaura Cross-Coupling Reactions between Sulfamates and Potassium Boc-Protected Aminomethyltrifluoroborates / Molander, G. A.*; Shin, I. Org. Lett. 2013, 15, 2534.
◾ Potassium Boc-Protected Secondary Aminomethyltrifluoroborates: Synthesis and Suzuki–Miyaura Cross-Coupling Reactions / Molander, G. A.*; Shin, I. Org. Lett. 2012, 14, 4458.
◾ Suzuki–Miyaura Cross-Coupling Reactions of Potassium Boc-Protected Aminomethyltrifluoroborate with Aryl and Hetaryl Mesylates / Molander, G. A.*; Shin, I. Org. Lett. 2012, 14, 3138.
◾ Synthesis and Suzuki–Miyaura Cross-Coupling Reactions of Potassium Boc-Protected Aminomethyltrifluoroborate with Aryl and Hetaryl Halides / Molander, G. A.*; Shin, I. Org. Lett. 2011, 13, 3956.
◾ Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling Reactions of Enantiomerically Enriched Potassium β-Trifluoroboratoamides with Various Aryl- and Hetaryl Chlorides / Molander, G. A.*; Shin, I.; Jean-Gérard, L. Org. Lett. 2010, 12, 4384.
◾ Total Synthesis of trans-Dihydronarciclasine through a Highly endo-Selective Diels-Alder Cycloaddition of 3,5-Dibromo-2-pyrone / Shin, I.-J.; Choi, E.-S.; Cho, C.-G.* Angew. Chem. Int. Ed. 2007, 46, 2303.
◾ Synthesis of Medium Sized Rings from the Cycloadducts of 3,5-Dibromo-2-pyrone via a Radical Mediated Fragmentation Reaction / Choi, J.-H.; Shin, I.-J.; Choi, E.-S.; Cho, C.-G.* Bull. Korean Chem. Soc. 2006, 27, 2091.
◾ Regioselective [5,5]-Sigmatropic Rearrangement Reactions of Aryl Hydrazides / Kang, H.-M.; Lim, Y.-K.; Shin, I.-J.; Kim, H.-Y.; Cho, C.-G.* Org. Lett. 2006, 8, 2047.
저널 논문
◾ Recent Advances in One-Pot Modular Synthesis of 2-Quinolones, MOLECULES, vol.25 No.22, 2020신인지
◾ Development and structure-activity relationship study of SHP2 inhibitor containing 3,4,6-trihydroxy-5-oxo-5H-benzo[7]annulene, BIOORGANIC MEDICINAL CHEMISTRY LETTERS, vol.30 No.1, 2020신인지
학술대회
◾ Seungmi Lee, Inji Shin, Palladium-catalyzed cross-coupling reaction by the use of reverse polarity of silyl ketimines, Korean Chemical Society Poster presentation, Online meeting, 2020신인지
◾ 조승진, 김보희, 신인지, Palladium-Catalyzed Coupling Reactions of Imine Anion Equivalent of Silyl-Ketimines, 제124회 대한화학회 Organic Chemistry Poster Presentation, 창원 컨벤션센터, 2019신인지
◾ 김보희, 조승진, 손정훈, 고범석, 신인지, Development and structure-activity relationship study of SHP2 inhibitors, 124회 대한화회학 학술발표회 Midicinal Chemistry Poster Presenation, 창원 컨벤션센터, 2019신인지
연구프로젝트
◾ 비타민C 유도체 개발, 여명바이오켐(주), 2020.07.~2020.12.신인지
◾ 마리골드 추출물을 이용한 비누화 반응에서 루테인의 메소지아잔틴으로의 이성질화 되는 반응의 연관성 검토, 대한켐텍주식회사, 2020.03.~2020.06.신인지
◾ 전이금속촉매를 이용한 연속적 Si-Si/C-Si 결합 활성화 반응 연구, 한국연구재단, 2019.03.~2021.02.신인지
수상
◾ 2020학년도 교육분야 우수교육상, 2020학년도 교육분야 우수교원 포상, 서울과학기술대학교, 2021신인지

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